High content screening

Misvik biology offers multi-parameter image-based cytometry for time- and cost-efficient information-intensive exploratory studies for discovery and lead development. Our R&D infrastructure includes state-of-the-art high-content microcopy instrumentation, propietary image cytometry pipeline, versatile panels of phenotype assays and chemical compound libraries and genome-wide siRNA and miRNA libraries.

galleryif1

APPLICATIONS

Phenotypic response profiling for small molecules and biologicals in high-content format. Comprehensive panel of imaging-based surrogate assays for cellular processes. Cell response phenotyping using 2D & 3D cell culture models. Phenotypic characterisation of cellular toxicity mechanisms. Adaptation of customers’ existing cell response assays for HTS.

 

MISVIK HIGH-CONTENT SCREENING ASSAYS FOR

Cell proliferation                                                   Cell adhesion

Checkpoint signaling                                            Vesicular trafficking

Apoptosis/Senescence/Autophagy                    Cell-cell junctions/ Cell polarization

Epithelial cell diffenrentiation                            Cytoskeletal remodelling

Matrix assembly                                                     DNA damage and repair responses